Recent Overview on Synthesis of 2-Mercaptobenzimidazole Derivatives and its Activities

A novel series 2-(1H-benzimidazol-2-ylsulfanyl) -N-(4-oxo-2-phenyl-thiazolidin-3yl) Various aldehydes and 2-acetamides have been used to synthesise -acetamide 5a–j (5-phenyl-[1,3,4]-oxadiazol-2-ylmethylsulfanyl) - 1H-benzimidazole 6a–j derived from a variety of benzoic acids. These compounds were tested in vitro for antibacterial activity against Gram positive bacteria Staphylococcus aureus Enterococcus faecalis, negative Klebsiella pneumoniae Escherichia coli, antifungal Aspergillus fumigatus Candida albicans. The cytotoxic properties brine shrimp investigated using bioassay. Compounds 5b, 5d, 5g, 5i, 6b, 6e, 6f, 6i demonstrated excellent panel microorganisms, according the results. 6h, found good activities. Elements, IR, 1H-NMR, 13C-NMR, MS characterise all newly synthesised compounds.
 Keywords: Antibacterial, Antifungal, 4-Thiazolidinone,1,3,4-Oxadiazole, Cytotoxicity.